UDP-glucuronosyltransferase-2B17 (C19-steroid specific UDP-glucuronosyltransferase, UGT2B17)

Function

• UDPGT is of major importance in the conjugation & subsequent elimination of potentially toxic xenobiotics & endogenous compounds
• major substrates are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT)

UDP-glucuronate + acceptor
              <-->
UDP + acceptor beta-D-glucuronoside

Structure

belongs to the UDP-glycosyltransferase family

Compartment

microsome

Expression

• expressed in various tissues including liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin & prostate

More general terms

• UDP-glucuronosyltransferase-2B (UDPGT-2B)

Database

• OMIM: https://mirror.omim.org/entry/601903
• UniProt: http://www.uniprot.org/uniprot/O75795.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7367