carnitine palmitoyltransferase 1 (CPT1)

Function

• CPT1 transfers acyl groups of long chain fatty acids from CoA to carnitine at the cytoplasmic surface of the inner mitochondrial membrane
• CPT2 transfers the acyl group back to CoA on the matrix surface of the membrane
• carnitine palmitoyl transferases (CPT) function primarily in the mitochondrial transport of fatty acyl CoA's with chain lengths of C12-C18
• shorter chain fatty acids can cross the inner mitochondrial membrane directly & be converted to their CoA derivatives in the mitochondrial matrix
• thus beta oxidation of C4-C10 is carnitine independent.

Laboratory

• carnitine palmitoyltransferase 1 in fibroblasts
• carnitine palmitoyltransferase 1 in leukocytes

More general terms

• carnitine palmitoyltransferase

More specific terms

• carnitine palmitoyltransferase-1A, liver isoform (CPT1A, CPT1)
• carnitine palmitoyltransferase-1B, muscle isoform (CPT1B, KIAA1670)