B[0,+]-type amino acid transporter 1 (B[0,+]AT; glycoprotein-associated amino acid transporter b0,+AT1; SLC7A9; BAT1)

Function

• role in high-affinity, Na+ independent transport of cystine & neutral & dibasic amino acids (system b(0,+)-like activity)
• high-affinity reabsorption of cystine in the kidney tubule (putative)

Structure

• disulfide-linked heterodimer with the amino acid transport protein SLC3A1

Compartment

membrane

Expression

• expressed in kidney, small intestine, liver, placenta

Pathology

• defects in SLC7A9 are a cause of non-type 1 cystinuria

More general terms

• solute carrier family 7 (SLC7, SLC7A)
• transmembrane 12 protein

Database

• OMIM: https://mirror.omim.org/entry/220100
• OMIM: https://mirror.omim.org/entry/604144
• UniProt: http://www.uniprot.org/uniprot/P82251.html