solute carrier family 7 member 10 (SLC7A10, Asc-type amino acid transporter 1, Asc-1)

Function

• Na+ independent, high affinity transport of small neutral D-amino acids & L-amino acids
• may play a role in modulation of glutamatergic transmission via mobilization of D-serine at synapses
• disulfide-linked heterodimer with SLC3A2

Structure

• belongs to the amino acid-polyamine-organocation (APC) superfamily

Compartment

membrane

Expression

• expressed in brain, heart, kidney, liver, lung, pancreas, placenta, & skeletal muscle.

Pathology

• defects in SLC7A10 may be involved in cystinuria

More general terms

• transmembrane 9 protein
• solute carrier family 7 (SLC7, SLC7A)

Additional terms

• cystinuria

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5630
• OMIM: https://mirror.omim.org/entry/607959
• UniProt: http://www.uniprot.org/uniprot/Q9NS82.html