phosphatidate cytidylyltransferase 1 (CDP-diglyceride synthetase 1, CDP-diglyceride pyrophosphorylase 1, CDP-diacylglycerol synthase 1, CDS 1, CTP:phosphatidate cytidylyltransferase 1, CDP-DAG synthase 1, CDP-DG synthetase 1, CDS1, CDS)

Function

• phospholipid biosynthesis
• provides CDP-diacylglycerol, precursor for synthesis of
  • phosphatidylinositol (PtdIns)
  • phosphatidylglycerol
  • cardiolipin
• overexpression may amplify cellular signaling responses from cytokines
• role in signal transduction in retina & neural cells

CTP + phosphatidate = diphosphate + CDP-diacylglycerol

Cofactor: Mg+2

Structure

• belongs to the CDS family

Compartment

endoplasmic reticulum membrane, cytoplasmic face

Expression

• expressed in adult tissues including placenta, brain, small intestine, ovary, testis, prostate
• expressed in fetal kidney, lung, brain > fetal liver

More general terms

• nucleotidyltransferase
• transmembrane 6 protein

Database

• OMIM: https://mirror.omim.org/entry/603548
• UniProt: http://www.uniprot.org/uniprot/Q92903.html