NADPH oxidase homolog 1 (NOX-1, NOH-1, NADH/NADPH mitogenic oxidase subunit P65-MOX, mitogenic oxidase 1, MOX1, NOX1, NOH1)

Function

• NOH-1S is a voltage-gated proton channel
  • mediates H+ currents of resting phagocytes & other tissues
  • participates in the regulation of cellular pH
  • blocked by Zn+2
• NOH-1L is a pyridine nucleotide-dependent oxidoreductase
  • generates superoxide
  • conduct H+ ions as part of its electron transport

Cofactor: NADP, FAD

Structure

• contains 1 ferric oxidoreductase domain, residues 54-545; oxidase activity is potentiated by NOXO1, via residues 397-536

Alternative splicing

named isoforms=3

Expression

• NOH-1L is expressed in colon, uterus, prostate, colon carcinoma, but NOT in peripheral blood leukocytes
• NOH-1S is detected only in colon & colon carcinoma cells

More general terms

• transmembrane 6 protein

Database

• OMIM: https://mirror.omim.org/entry/300225
• UniProt: http://www.uniprot.org/uniprot/Q9Y5S8.html