dolichyldiphosphatase 1; dolichyl pyrophosphate phosphatase 1 (DOLPP1)

Function

• required for efficient N-glycosylation
• necessary for maintaining optimal levels of dolichol-linked oligosaccharides
• hydrolyzes dolichyl pyrophosphate much faster than dolichyl monophosphate
• does not act on phosphatidate
• protein modification; protein glycosylation

dolichyl diphosphate + H2O = dolichyl phosphate + phosphate

Structure

belongs to the dolichyldiphosphatase family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein (putative)

More general terms

• pyrophosphatase (diphosphohydrolase)
• transmembrane 4 protein

Additional terms

• dolichol pyrophosphate

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57171
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57171
• UniProt: http://www.uniprot.org/uniprot/Q86YN1.html