phosphatidylethanolamine N-methyltransferase; PEAMT (PEMT, PEMPT, PNMT)

Function

• catalyzes three sequential methylation of phosphatidylethanolamine by AdoMet, thus producing phosphatidylcholine
• the first methylation is rate-limiting

S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine

Structure

• belongs to the PEMT/PEM2 methyltransferase family

Compartment

• endoplasmic reticulum membrane
• mitochondrial membrane
• multi-pass membrane protein (putative)
• found in endoplasmic reticulum where most PEMT activity is generated & in mitochondria

Alternative splicing

named isoforms=2

More general terms

• N-methyltransferase
• transmembrane 4 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10400
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10400
• OMIM: https://mirror.omim.org/entry/602391
• UniProt: http://www.uniprot.org/uniprot/Q9UBM1.html