phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (TPTE & PTEN homologous inositol lipid phosphatase, lipid phosphatase TPIP, TPTE2, TPIP)

Function

-..........-

   phosphatidylinositol 3,4,5-trisphosphate + H2O
                         <-->
   phosphatidylinositol 4,5-bisphosphate + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily
• contains 1 C2 tensin-type domain
  • contains 1 phosphatase tensin-type domain

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=4

Expression

• isoform 3 is expressed in testis, brain, stomach
• isoform 4 is testis-specific

More general terms

• phosphomonoesterase
• transmembrane 3 protein

Database

• OMIM: https://mirror.omim.org/entry/606791
• UniProt: http://www.uniprot.org/uniprot/Q6XPS3.html