ceramide glucosyltransferase; GLCT-1; glucosylceramide synthase; GCS; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase (UGCG)

Function

• catalyzes 1st glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide
• may also serve as a flippase
• lipid metabolism; sphingolipid metabolism

Structure

belongs to the glycosyltransferase 2 family

Compartment

• endoplasmic reticulum membrane; multi-pass membrane protein

Expression

found in all tissues examined

More general terms

• glucosyl transferase
• transmembrane 3 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7357
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7357
• OMIM: https://mirror.omim.org/entry/602874
• UniProt: http://www.uniprot.org/uniprot/Q16739.html