tumor suppressor candidate 5 (protein located at 17p13.1, TUSC5, LOST1)

Function

• may be involved in fat metabolism

Structure

belongs to the CD225 family

Compartment

membrane

Expression

• expressed in heart, mammary gland, adrenal gland, stomach, smooth muscle & skeletal muscle > brain & lung
• expressed in fetal brain

Pathology

• strongly down-regulated inlung cancer tissues, due to hypermethylation of the corresponding locus

More general terms

• transmembrane 2 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IXB3.html