ectonucleoside triphosphate diphosphohydrolase 5; NTPDase 5; CD39 antigen-like 4; ER-UDPase; nucleoside diphosphatase (ENTPD5, CD39L4, PCPH)

Function

• likely to promote reglycosylation reactions involved in glycoproteins folding & quality control in the endoplasmic reticulum
• hydrolyzes UDP, GDP & IDP but not other nucleoside diphosphates
• does not hydrolyze nucleoside monophosphates or nucleoside triphosphates
• does not hydrolyze thiamine pyrophosphate

Cofactor: Ca+2, Mg+2

Structure

belongs to the GDA1/CD39 NTPase family

Compartment

endoplasmic reticulum lumen (putative)

Expression

• expressed in adult liver, kidney, prostate, testis & colon
• much weaker expression in other tissues

More general terms

• CD39 like protein

Additional terms

• CD39; ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; ecto-ATP diphosphohydrolase; ATPDase; lymphoid cell activation antigen; ecto-apyrase (ENTPD1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=957
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:957
• OMIM: https://mirror.omim.org/entry/603162
• UniProt: http://www.uniprot.org/uniprot/O75356.html