beta tryptase-1 (tryptase-1, TPSAB1, TPSB1)

Function

• tryptase is the major neutral protease present in mast cells
• secreted upon the coupled activation-degranulation
• preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin

Structure

• homotetramer
• belongs to the peptidase S1 family, tryptase subfamily
• contains 1 peptidase S1 domain

Compartment

• secreted
• released from secretory granules upon mast cell activation

Alternative splicing

named isoforms=2

More general terms

• beta tryptase (trypase-beta)

Database

• OMIM: https://mirror.omim.org/entry/191081
• UniProt: http://www.uniprot.org/uniprot/Q15661.html