neurexin-3-alpha; neurexin III-alpha (NRXN3, KIAA0743)

Function

• neuronal cell surface protein
• may be involved in cell recognition & cell adhesion
• may mediate intracellular signaling
• the laminin G-like domain 2 binds to NXPH1
• specific isoforms bind to alpha-dystroglycan
• the cytoplasmic C-terminal region binds to CASK (putative)

Structure

• belongs to the neurexin family
• contains 3 EGF-like domains
• contains 6 laminin G-like domains

Compartment

membrane Alternative promoter: yes

Alternative splicing

named isoforms=2

Expression

• predominantly expressed in brain
• expressed at low levels in the inner & out layers of cortex, striatum, septum & reticular nucleus of the thalamus

More general terms

• neurexin-3

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9369
• OMIM: https://mirror.omim.org/entry/600567
• UniProt: http://www.uniprot.org/uniprot/Q9Y4C0.html