glypican-3; intestinal protein OCI-5; GTR2-2; MXR7; (GPC3, OCI5)

Function

• cell surface proteoglycan that bears heparan sulfate
• may be involved in the suppression/modulation of growth in predominantly mesodermal tissues & organs
• may play a role in modulation of IGF2 function
• may regulate growth & tumor predisposition

Structure

belongs to the glypican family

Compartment

• cell membrane; lipid-anchor
• GPI-anchor extracellular side (putative)
• secreted, extracellular space (putative)

Expression

highly expressed in lung, liver & kidney

Pathology

• defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome

More general terms

• glypican

Database

• UniProt: http://www.uniprot.org/uniprot/P51654.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2719
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2719
• OMIM: https://mirror.omim.org/entry/300037
• OMIM: https://mirror.omim.org/entry/312870