alpha-S1-casein; contains: casoxin-D (CSN1S1, CASA, CSN1)

Function

• important role in the capacity of milk to transport Ca+2 phosphate
• not glycosylated
• heteromultimers of alpha-s1 casein & kappa-casein

Structure

• disulfide-linked
• belongs to the alpha-casein family

Compartment

secreted

Alternative splicing

named isoforms=3

Expression

• mammary gland specific
• secreted in milk

Notes

• in milk, the alpha s1- & beta-caseins precipitate in presence of Ca+2 (so-called Ca+2-sensitive caseins)
• kappa-casein prevents the precipitation of the other caseins by Ca+2 through formation of large stable colloidal particles termed micelles

More general terms

• casein

More specific terms

• casoxin D

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1446
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1446
• OMIM: https://mirror.omim.org/entry/115450
• UniProt: http://www.uniprot.org/uniprot/P47710.html