LIM/homeodomain protein LHX4; LIM homeobox protein 4 (LHX4)

Function

• role in the development of respiratory control mechanisms (putative)
• role in the normal growth & maturation of the lung (putative)

Structure

• contains 1 homeobox DNA-binding domain
• contains 2 LIM Zn+2-binding domains

Compartment

nucleus (putative)

Pathology

• defects in LHX4 are the cause of Machinis syndrome
• chromosomal translocation t(1;14)(q25;q32) involving LHX4 with IGHG1 may be a cause of acute lymphoblastic leukemia

More general terms

• LIM/homeodomain protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8988
• OMIM: https://mirror.omim.org/entry/602146
• OMIM: https://mirror.omim.org/entry/606606
• UniProt: http://www.uniprot.org/uniprot/Q969G2.html