insulin gene enhancer protein ISL-1; ISL1 transcription factor; islet-1 (ISL1)

Function

• binds to cis-acting domain of the insulin gene enhancer

Structure

• contains 1 homeobox DNA-binding domain
• contains 2 LIM Zn+2-binding domains

Compartment

nucleus

Expression

• expressed in subsets of neurons of the adrenal medulla & dorsal root ganglion, inner nuclear & ganglion cell layers in the retina, pineal & regions of brain

More general terms

• LIM/homeodomain protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3670
• OMIM: https://mirror.omim.org/entry/600366
• UniProt: http://www.uniprot.org/uniprot/P61371.html