BTB/POZ domain-containing protein KCTD20 (KCTD20, C6orf69)

^[1]^[2]^[3]^[4]

Function

component of a complex containing MARK4
promotes phosphorylation of AKT family members^[1]
- positive regulator of AKT^[3]
suppresses or inhibits lysosomes^[1]

↑ ^1.0 ^1.1 ^1.2 UniProt http://www.uniprot.org/uniprot/Q7Z5Y7.html
↑ Berlind JE, Lai JD, Lie C et al KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids. Neuron March 5, 2025 PMID: https://www.ncbi.nlm.nih.gov/pubmed/40049159 https://www.cell.com/neuron/abstract/S0896-6273(25)00114-X
↑ ^3.0 ^3.1 Nawa M, Matsuoka M. KCTD20, a relative of BTBD10, is a positive regulator of Akt. BMC Biochem. 2013 Oct 24;14:27. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24156551 PMCID: PMC3827329 Free PMC article
↑ Zhang X, Zhou H, Cai L, Fan C, Liu Y, Wang L, Li Q, Miao Y. Kctd20 promotes the development of non-small cell lung cancer through activating Fak/AKT pathway and predicts poor overall survival of patients. Mol Carcinog. 2017 Sep;56(9):2058-2065. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28398603