cyclin B2 (CCNB2)

Function

• essential for the control of the cell cycle at the G2/M (mitosis) transition
• accumulates steadily during G2 & is abruptly destroyed at mitosis
• interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as
• maturation promoting factor (MPF)
• the cyclin subunit imparts substrate specificity to the complex

Structure

belongs to the cyclin family. cyclin AB subfamily

Expression

• G2/M-specific cyclin B2
• maximum concentrations are reached about at the G2/M boundary

More general terms

• cyclin B

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9133
• OMIM: https://mirror.omim.org/entry/602755
• UniProt: http://www.uniprot.org/uniprot/O95067.html