sry-box-3 protein; transcription factor SOX-3 (sox3)

Structure

contains 1 HMG box DNA-binding domain

Compartment

nucleus

Pathology

• defects in SOX3 are the cause of:
  • infundibular hypoplasia & hypopituitarism
  • mental retardation X-linked with isolated GH deficiency

More general terms

• sox protein

Database

• UniProt: http://www.uniprot.org/uniprot/P41225.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6658
• OMIM: https://mirror.omim.org/entry/313430
• OMIM: https://mirror.omim.org/entry/300123
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6658