sry-box-1 protein (sox1)
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Function
transcriptional activator (putative)
Structure
contains 1 HMG box DNA-binding domain
Compartment
nucleus (probable)
Expression
- mainly in the developing central nervous system
Pathology
- antibodies against SOX1 associated with cancers
- 64% of the patients with Lambert-Eaton myasthenic syndrome secondary to small-cell carcinoma of the lung; 0% in patients with idiopathic Lambert-Eaton syndrome
- 32% of cancer patients with anti-Hu-related syndromes
- 22% of patients with cancer, but without paraneoplastic syndrome
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O00570.html
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6656
- ↑ Sabater L et al. SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome. Neurology 2008 Mar 18; 70:924 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18032743
Lang B and Evoli A. SOX1 autoantibodies: Tumor markers in LEMS patients? Neurology 2008 Mar 18; 70:906 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18347313