dynein heavy chain 7, axonemal (ciliary dynein heavy chain 7, dynein heavy chain-like protein 2, HDHC2, DNAH7, KIAA0944)
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Function
- dynein heavy chain
- force generating protein of respiratory cilia
- produces force towards the minus ends of microtubules
- dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (putative)
Structure
- dynein complex consists of at least two heavy chains & a number of intermediate & light chains (putative)
- dynein heavy chains probably consist of an N-terminal stem (which binds cargo & interacts with other dynein components), & the head or motor domain
- the motor contains six tandemly- linked AAA domains in the head, which form a ring
- a stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 & AAA 5 & terminates in a microtubule-binding site
- seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain
- there are four well-conserved & two non-conserved ATPase sites, one per AAA domain
- probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (putative)
- belongs to the dynein heavy chain family
Compartment
cell projection, cilium axoneme
Alternative splicing
named isoforms=4
Expression
- detected in brain, testis & trachea
- detected in bronchial cells (at protein level)
- up-regulated during ciliogenesis (at protein level)