prostasin; serine protease 8 [contains: prostasin light chain & prostasin heavy chain] (PRSS8)

Function

• possesses a trypsin-like cleavage specificity

Structure

• heterodimer of two chains, light & heavy, held by a disulfide bond
• belongs to the peptidase S1 family
• contains 1 peptidase S1 domain

Compartment

• prostasin: cell membrane
• prostasin light chain & prostasin heavy chain
  • secreted, extracellular space
  • secreted after cleavage of its C-terminus
  • found in the seminal fluid

Expression

• found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus & renal proximal tubular cells
• in prostate, it may be synthesized in epithelial cells, secreted into the ducts, & excreted into the seminal fluid

More general terms

• serine protease trypsin family
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5652
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5652
• OMIM: https://mirror.omim.org/entry/600823
• UniProt: http://www.uniprot.org/uniprot/Q16651.html