P2U/P2Y2 purinoceptor; P2Y purinoceptor 2; P2U purinoceptor 1 (P2RY2, P2RU1, P2Y2, P2U1)

Function

• receptor for ATP & UTP
• coupled to G-proteins that activate phosphatidylinositol-Ca+2 second messenger system
• affinity is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane; multi-pass membrane protein

Expression

spleen, testis, kidney, liver, lung, heart & brain

More general terms

• P2Y purinoceptor or P2Y purinergic receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5029
• OMIM: https://mirror.omim.org/entry/600041
• UniProt: http://www.uniprot.org/uniprot/P41231.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5029