melanopsin; opsin-4 (OPN4, MOP)

Function

• photoreceptor required for regulation of circadian rhythm
• contributes to pupillar reflex & other non-image forming responses to light
• may be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (putative)

Structure

• belongs to the G-protein coupled receptor 1 family, Opsin subfamily

Compartment

• membrane
• found in soma, dendrites & proximal part of axons of certain retinal ganglion cells (putative)

Expression

• expressed in retina
• expression is restricted within the ganglion & amacrine cell layers of the retina

More general terms

• opsin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=94233
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:94233
• OMIM: https://mirror.omim.org/entry/606665
• UniProt: http://www.uniprot.org/uniprot/Q9UHM6.html