LAG1 longevity assurance homolog 5; ceramide synthase 5 (CERS5, LASS5)

Function

• ceramide synthesis
• when overexpressed in cells, LASS5 is involved in production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl- (C16) ceramide) independent of fumonisin B1

Structure

• contains 1 homeobox DNA-binding domain
• contains 1 TLC (TRAM/LAG1/CLN8) domain

Compartment

• nuclear membrane
• endoplasmic reticulum membrane
• multi-pass membrane protein (putative)

More general terms

• transmembrane 6e protein
• LAG1 longevity assurance homolog
• phosphoprotein
• glycoprotein

Additional terms

• Lag1 (longevity assurance gene 1) transcription factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=91012
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:91012
• UniProt: http://www.uniprot.org/uniprot/Q8N5B7.html