LAG1 longevity assurance homolog 4; ceramide synthase 4; cerS4 (CERS4, LASS4)

Function

• ceramide synthesis
• may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity
• when overexpressed in cells, LASS4 is involved in production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) independent of fumonisin B1 (putative)

Structure

• contains 1 homeobox DNA-binding domain
• contains 1 TLC (TRAM/LAG1/CLN8) domain

Compartment

• nucleal membrane;
• endoplasmic reticulum membrane
• multi-pass membrane protein (putative)

More general terms

• LAG1 longevity assurance homolog
• phosphoprotein

Additional terms

• Lag1 (longevity assurance gene 1) transcription factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79603
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79603
• UniProt: http://www.uniprot.org/uniprot/Q9HA82.html