DnaJ homolog subfamily C member 15 (methylation-controlled J protein, MCJ, DNAJC15, DNAJD1, HSD18)
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Structure
- contains 1 J domain
Compartment
membrane
Expression
Pathology
- absent or down-regulated in many advanced cases of ovarian cancer, due to hypermethylation & allelic loss
- loss expression correlates with increased resistance to antineoplastic drugs, including cisplatin