arachidonate-15-lipoxygenase type 2 (ALOX15B)

Function

• leukotriene synthesis
• converts arachidonic acid exclusively to 15S-HPETE (linoleic acid is less well metabolized)

Cofactor: Fe+2

Structure

• belongs to the lipoxygenase family
• contains 1 PLAT domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=4

Expression

expressed in hair, prostate, lung & cornea

More general terms

• 15-lipoxygenase

Additional terms

• lipoxygenase cascade

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:247
• OMIM: https://mirror.omim.org/entry/603697
• UniProt: http://www.uniprot.org/uniprot/O15296.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=247