arachidonate-15-lipoxygenase (arachidonate omega-6 lipoxygenase, arachidonate 12/15 lipoxygenase, ALOX15)

Function

• leukotriene biosynthesis
• converts arachidonic acid to 15S-HPETE
• also 12-lipoxigenase activity
• acts on linoleic acid as well

Cofactor: Fe+2

Structure

• belongs to the lipoxygenase family
• contains 1 PLAT domain

Compartment

cytoplasm

More general terms

• 15-lipoxygenase

Additional terms

• lipoxygenase cascade

Database

• UniProt: http://www.uniprot.org/uniprot/P16050.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:246
• OMIM: https://mirror.omim.org/entry/152392
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=246