arachidonate-12-lipoxygenase 12R type (epidermis-type lipoxygenase 12, 12R-lipoxygenase, 12R-LOX, ALOX12B)

Function

• leukotrience biosynthesis
• converts arachidonic acid to 12R-HPETE

Cofactor: Fe+2

Expression

B-cells, hair follicles, foreskin keratinocytes, adult skin, psoriatic tissue.

Pathology

• defects in ALOX12B nonbullous congenital ichthyosiform erythroderma 1

More general terms

• 12-lipoxygenase; arachidonate-12-lipoxygenase

Additional terms

• lipoxygenase cascade
• nonbullous congenital ichthyosiform erythroderma 1

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:242
• OMIM: https://mirror.omim.org/entry/242100
• OMIM: https://mirror.omim.org/entry/603741
• UniProt: http://www.uniprot.org/uniprot/O75342.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=242