cytokeratin-74 (keratin, type-2 cytoskeletal 74, keratin-74, type-2 keratin-37, type-2 inner root sheath-specific keratin-K6irs4, keratin-5c, KRT74, K6IRS4, KB37, KRT5C, KRT6IRS4)
Jump to navigation
Jump to search
Function
- role in hair formation
- specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (probable)
Structure
- heterotetramer of two type-1 & two type-2 keratins
- belongs to the intermediate filament family
Expression
- highly expressed in hair follicles from scalp
- in hair, specifically present in the inner root sheath of the hair follicle
- present in the inner root sheath Huxley layer, but not in Henle layer or cuticle
- in the inner root sheath Huxley layer, expressed in specialized Huxley cells, termed 'Fluegelzellen, along the area of differentiated Henle cells (at protein level)