aldehyde dehydrogenase family 8 member A1 (aldehyde dehydrogenase 12, ALDH8A1, ALDH12)

Function

• converts 9-cis-retinal to 9-cis-retinoic acid
• as lower activity towards 13-cis-retinal
• much lower activity towards all-trans-retinal
• highest activity with benzaldehyde & decanal (in vitro)
• preference for NAD, also activity with NADP (in vitro)

Kinetic parameters:

• KM=17.5 uM for benzaldehyde
• KM=3.15 uM for 9-cis-retinal
• Optimum pH is 9

Structure

belongs to the aldehyde dehydrogenase family

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=3

Expression

• highly expressed in adult kidney & liver
• detected at lower levels in fetal liver & kidney

More general terms

• aldehyde dehydrogenase

Database

• OMIM: https://mirror.omim.org/entry/606467
• UniProt: http://www.uniprot.org/uniprot/Q9H2A2.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64577