aldehyde dehydrogenase 2, mitochondrial (acetaldehyde dehydrogenase 2, liver mitochondrial aldehyde dehydrogenase, ALDHI, ALDH-E2, ALDH2, ALDM)

Function

• ethanol utilization, 2nd step

an aldehyde + NAD+ + H2O = an acid + NADH

Structure

• homotetramer
• belongs to the aldehyde dehydrogenase family

Compartment

mitochondria matrix

Polymorphism

• allele ALDH2*2 is associated with a very high incidence of acute alcohol intoxication in Orientals & South American Indians, as compared to Caucasians
• 50% of orientals lack this enzyme

More general terms

• aldehyde dehydrogenase

Database

• UniProt: http://www.uniprot.org/uniprot/P05091.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:217
• OMIM: https://mirror.omim.org/entry/100650
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=217