choline/ethanolamine kinase; choline kinase beta; CKB; choline kinase-like protein; ethanolamine kinase; EK; ethanolamine kinase beta; EKB; choline/ethanolamine kinase beta; CKEKB (CHKB, CHETK, CHKL)

Function

• role in phospholipid biosynthesis
• catalyzes 1st step in phosphatidylethanolamine biosynthesis
• phosphorylates ethanolamine
• phosphorylates choline with lesser efficiency (contribution to phosphatidylcholine biosynthesis probably not significant)
• phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3
• homodimer, & heterodimer with CHKA

ATP + ethanolamine = ADP + O-phosphoethanolamine ATP + choline = ADP + O-phosphocholine

Kinetic parameters:

• KM=0.57 mM for choline
• KM=2.9 mM for ethanolamine

Structure

belongs to the choline/ethanolamine kinase family

Alternative splicing

named isoforms=2

Notes

• protein produced by a bicistronic gene which also produces the CPT1B protein from a non-overlapping reading frame

More general terms

• kinase or ATP-phosphotransferase
• phosphoprotein

Additional terms

• choline kinase (CHKA)
• ethanolamine kinase 1; EKI 1 (ETNK1, EKI1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1120
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1120
• OMIM: https://mirror.omim.org/entry/612395
• UniProt: http://www.uniprot.org/uniprot/Q9Y259.html