deoxyguanosine kinase, mitochondrial; dGK (DGUOK, DGK)

Function

• required for the phosphorylation of several deoxyribonucleosides & certain nucleoside analogs widely employed as antiviral & chemotherapeutic agents

ATP + deoxyguanosine = ADP + dGMP

Structure

• homodimer
• belongs to the DCK/DGK family

Compartment

mitochondria

Alternative splicing

named isoforms=5

Expression

• ubiquitous
• highest expression in muscle, brain, liver & lymphoid tissues

Pathology

• defects in DGUOK are the cause of mitochondrial DNA depletion syndrome type 3

More general terms

• kinase or ATP-phosphotransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1716
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1716
• OMIM: https://mirror.omim.org/entry/251880
• OMIM: https://mirror.omim.org/entry/601465
• UniProt: http://www.uniprot.org/uniprot/Q16854.html