fucose-1-phosphate guanylyltransferase; GDP-L-fucose diphosphorylase; GDP-L-fucose pyrophosphorylase (FPGT, GFPP)

Function

• catalyzes the formation of GDP-L-fucose from GTP & L-fucose-1-phosphate
• functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins & glycolipids

GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose

Compartment

cytoplasm

Alternative splicing

named isoforms=4

Expression

expressed in many tissues

Notes

• a naturally occurring readthrough transcript produces a FPGT-TNNI3K fusion protein

More general terms

• nucleotidyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8790
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8790
• OMIM: https://mirror.omim.org/entry/603609
• UniProt: http://www.uniprot.org/uniprot/O14772.html