hemK methyltransferase family member 2; M.HsahemK2P; N6-adenine-specific DNA methyltransferase 1 (N6AMT1, C21orf127, HEMK2, PRED28)

Function

• heterodimeric methyltransferase
• catalyzes N5-methylation of ETF1 on Gln-185, using S-adenosyl L-methionine as methyl donor
• ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated
• heterodimer with TRMT112

Structure

belongs to the hemK family

Alternative splicing

named isoforms=2

More general terms

• N-methyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29104
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29104
• UniProt: http://www.uniprot.org/uniprot/Q9Y5N5.html