histamine N-methyltransferase (HNMT)

Function

• inactivates histamine by N-methylation
• role in degrading histamine & in regulating airway response to histamine

S-adenosyl-L-methionine + histamine
    <-->
S-adenosyl-L-homocysteine + N-methylhistamine

Structure

• monomer
• belongs to the methyltransferase superfamily, HNMT family

Compartment

cytoplasm

Polymorphism

• variant Ile-105 has a reduced activity & seems to be linked with a susceptibility to asthma

More general terms

• N-methyltransferase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P50135.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3176
• OMIM: https://mirror.omim.org/entry/605238