microsomal glutathione S-transferase 1 (microsomal GST-1, microsomal GST-I, MGST1, GST12, MGST)

Function

• conjugation of reduced glutathione to a wide number of exogenous & endogenous hydrophobic electrophiles
• wide substrate specificity
• activated by N-ethylmaleimide, except in the testis

RX + glutathione = HX + R-S-glutathione

Structure

• homotrimer
• belongs to the MAPEG family

Compartment

• microsome (putative)
• mitochondrion outer membrane
• peripheral membrane (putative)

Expression

highly expressed in liver

More general terms

• microsomal glutathione S-transferase

Database

• UniProt: http://www.uniprot.org/uniprot/P10620.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4257
• OMIM: https://mirror.omim.org/entry/138330