glutathione S-transferase mu-3; M3; GST5; GSTB; testis/brain glutathione S-transferase; GST class-mu 3; hGSTM3-3 (GSTM3)

Function

• conjugation of reduced glutathione to a wide number of exogenous & endogenous hydrophobic electrophiles
• may govern uptake & detoxification of both endogenous compounds & xenobiotics at the testis & brain blood barriers

RX + glutathione = HX + R-S-glutathione

Structure

• homodimer
• belongs to the GST superfamily, Mu family
• N-terminus is blocked

Compartment

cytoplasm

Expression

testis & brain

More general terms

• glutathione S-transferase mu

Database

• UniProt: http://www.uniprot.org/uniprot/P21266.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2947
• OMIM: https://mirror.omim.org/entry/138390
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2947