cytoplasmic aspartate aminotransferase (GOT1, transaminase A)

Function

• transaminase; catalyzes formation of oxaloacetate & glutamate from aspartate & 2-oxoglutarate

L-aspartate + 2-oxoglutarate <--> oxaloacetate + L-glutamate

Cofactor: pyridoxal phosphate

Structure

• homodimer
• belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family

Compartment

cytoplasm

More general terms

• aspartate aminotransferase

Database

• UniProt: http://www.uniprot.org/uniprot/P17174.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2805
• OMIM: https://mirror.omim.org/entry/138180