branched-chain amino-acid transaminase-1 (cytosolic branched-chain amino acid aminotransferase, BCATc, protein ECA39, BCAT1, BCT1, ECA39)

Function

• catalyzes the 1st reaction in the catabolism of essential branched chain amino acids leucine, isoleucine, & valine

L-leucine + 2-oxoglutarate
        <-->
4-methyl-2-oxopentanoate + L-glutamate

Cofactor: pyridoxal phosphate

Structure

• homodimer (putative)
• belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family

Compartment

cytoplasm

Expression

• during embryogenesis, expressed in the brain & kidney

Pathology

• overexpressed in C-myc induced tumors including Burkitt's lymphoma

More general terms

• branched-chain amino-acid transaminase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:586
• OMIM: https://mirror.omim.org/entry/113520
• UniProt: http://www.uniprot.org/uniprot/P54687.html