1-acyl-sn-glycerol-3-phosphate acyltransferase eta; 1-AGP acyltransferase 7; 1-AGPAT 7, lysophosphatidic acid acyltransferase eta; LPAAT-eta; acyltransferase-like 3 (AGPAT7, LPCAT4, AYTL3)
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Function
- converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (putative)
- de novo phospholipid biosynthesis, 2nd step
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate <--> CoA + 1,2-diacyl-sn-glycerol 3-phosphate
Structure
- belongs to 1-acyl-sn-glycerol-3-phosphate acyltransferase family
Compartment
endoplasmic reticulum membrane
Alternative splicing
named isoforms=3
Expression
- widely expressed
- expressed in uterus, thymus, pancreas, skeletal muscle, bladder, stomach, lung & testis