N-acetyltransferase 6; protein fusion-2; protein fus-2 (NAT6, FUS2)

Function

• N-acetylation of peptides with N-terminal Met followed by Asp/Glu/Asn
• tumor suppressor (putative)

Structure

• belongs to the acetyltransferase family
• contains 1 N-acetyltransferase domain

Compartment

cytoplasm

Expression

• strongly expressed in heart, skeletal muscle > brain, pancreas > kidney, liver, lung
• no expression in placenta

Pathology

• defects in NAT6 found in non-small cell lung cancer cell lines

More general terms

• acetyltransferase

Additional terms

• non-small cell carcinoma of the lung (NSCLC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=24142
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:24142
• OMIM: https://mirror.omim.org/entry/607073
• UniProt: http://www.uniprot.org/uniprot/Q93015.html