sialidase-4 (N-acetyl-alpha-neuraminidase 4, NEU4)

Function

• sialidase activity towards synthetic substrates
• hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid

Kinetic parameters:

• Optimum pH is 3.2

Structure

• belongs to the glycosyl hydrolase 33 family
• contains 3 BNR repeats

Compartment

peripheral membrane

Expression

ubiquitous but highest level in liver

More general terms

• sialidase

Database

• OMIM: https://mirror.omim.org/entry/608527
• UniProt: http://www.uniprot.org/uniprot/Q8WWR8.html