sialidase-2; cytosolic sialidase; N-acetyl-alpha-neuraminidase 2 (NEU2)

Function

• hydrolyzes sialylated compounds
• hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid & synthetic substrates

Structure

• belongs to the glycosyl hydrolase 33 family
• contains 2 BNR repeats

Compartment

cytoplasm (putative)

Expression

• expressed in skeletal muscle, fetal liver & embryonic carcinoma cell line NT2D1

More general terms

• sialidase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4759
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4759
• OMIM: https://mirror.omim.org/entry/605528
• UniProt: http://www.uniprot.org/uniprot/Q9Y3R4.html