3-hydroxybutyrate dehydrogenase type 2 (R-beta-hydroxybutyrate dehydrogenase, dehydrogenase/reductase SDR family member 6, oxidoreductase UCPA, BDH2, DHRS6, UNQ6308/PRO20933)

Function

• dehydrogenase

(R)-3-hydroxybutanoate + NAD+ <--> acetoacetate  + NADH

Kinetic parameters:

• KM=60 uM for NAD
• KM=10 mM for R-hydroxybutyrate
• Vmax=82 nmol/min/mg enzyme (at 30 degrees Celsius)
• Optimum pH is 7.5-9.0

Structure

• homotetramer
• belongs to the short-chain dehydrogenases/reductases (SDR) family

Compartment

cytoplasm

Alternative splicing

named isoforms=2

More general terms

• dehydrogenase/reductase SDR family (DHRS)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BUT1.html