1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; acireductone dioxygenase (Fe(2+)-requiring); ARD; Fe-ARD; membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; MTCBP-1; submergence-induced protein-like factor; Sip-L (ADI1, MTCBP1, HMFT1638)
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Function
- aci-reductone dioxygenase (ARD) activity
- catalyzes formation of formate & 2-keto-4-methylthiobutyrate from 1,2-dihydroxy-3-keto-5-methylthiopentene
- 5-methylthioadenosine (MTA) methionine salvage pathway (yeast)
- down-regulates cell migration mediated by MMP14
- binds 1 Ni+2 per monomer, can also use other divalent metal cations
Structure
belongs to the acireductone dioxygenase (ARD) family
Compartment
- cell membrane, cytoplasmic side, nucleus
- localizes to plasma membrane when complexed to MMP14
Alternative splicing
named isoforms=2
Expression
- expressed in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle, kidney
Pathology
- necessary for hepatitis C virus replication in an otherwise non-permissive cell line